| Pair Name | Silibinin, Metformin | ||
| Phytochemical Name | Silibinin (PubChem CID: 31553 ) | ||
| Anticancer drug Name | Metformin (PubChem CID: 4091 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Silibinin, Metformin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Proliferation | |||
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Down-regulation | Expression | TERT | hsa7015 | |
| In Vitro Model | T-47D | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0553 |
| Result | The results provide evidence that synergistic antiproliferative effects of MET and SIL, linking to the down-regulation of Cyclin D1 and hTERT genes, and propose that MET+SIL may have therapeutic value in breast cancer therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition. Drug Res (Stuttg). 2018 Dec;68(12):710-716. doi: 10.1055/a-0631-8046. | Click |
